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Cardiovascular Expert Insights

Pharmacy Learning Network
Ranolazine is approved as an antianginal and is used as a second-line therapy in stable ischemic heart disease.1 The agent blocks the late sodium channels (INa) preventing a downstream rise in cytosolic Ca2+ concentrations.2  This translates into a decrease in left ventricular wall tension and an…
Pharmacy Learning Network
Non-steroidal anti-inflammatory drugs (NSAIDs) are one of the most commonly used drugs worldwide.  These agents have been associated with higher risk of acute myocardial infarction, stroke, heart failure, and renal failure.1-2 NSAID use appears to increase left ventricular end-diastolic and…
Pharmacy Learning Network
High blood pressure is the leading cause of heart disease and stroke, killing approximately 7.5 million people worldwide every year.1The number of people living with high blood pressure worldwide has doubled over the last 40 years, with the problem shifting from wealthy western countries to the…
Pharmacy Learning Network
James Matera, DO, from CentraState Medical Center in New Jersey, discusses how lipid disorders impact the management of chronic kidney disease (CKD), and whether statins are safe for use in patients with comorbid lipid disorders and CKD. James Matera:  Hi. My name is Dr. James Matera. I'm the…
Pharmacy Learning Network
Researchers recently found that vitamin D supplementation did not lower the incidence of invasive cancer or cardiovascular events. The study, a nationwide, randomized, placebo-controlled trial, was conducted by a research team led by, JoAnn Manson, MD, DrPH, and colleagues. The researchers sought…
Pharmacy Learning Network
Chronic heart failure with reduced ejection fraction (HFrEF) is associated with high risk of thromboembolic events.  Potential mechanisms for increased thrombosis include but are not limited to activation of thrombin-related pathways1 and blood stasis in dilated hypokinetic cardiac chambers and…
Pharmacy Learning Network
The body’s immune system helps protect against pathogens that cause infection. However, some pathogens overwhelm the immune system. When this happens, it can cause serious illness, especially in patients who are immunocompromised or have serious illness such as heart failure. An influenza infection…
Pharmacy Learning Network
Omega−3 fatty acids are polyunsaturated fatty acids (PUFAs).  Omega−3 fatty acids are important for normal metabolism.  There are three types of omega−3 fatty acids involved in human physiology α-linolenic acid, found in plant oils, and eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA),…
Pharmacy Learning Network
The 2017 American College of Cardiology/American Heart Association (ACC/AHA) Hypertension Guidelines lowered the thresholds for defining hypertension and the treatment goal for higher risk patients.1 The guideline was not universally accepted—the American College of Physicians and the American…
Pharmacy Learning Network
The FDA defines a supplement as a product “intended to add further nutritional value to the diet”.  Today, there are approximately 6000 companies producing 75,000 supplement products, with an astonishing 52% of the U.S. population taking supplements.  Supplements are a $37 billion industry.1…
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