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Interview

Reviewing Current Therapeutic Approaches for COVID-19 and Identifying What Is Still Needed


November 08, 2020

By Julie Gould 

arun kumarIn a new review posted online in International Immunopharmacology, a group of researchers compared collective data on the therapeutic advancements in mitigating the pandemic situation. Current data is still limited, and according to the researchers, further clinical investigations are needed.  

“The entire health care fraternity is engaged in endeavouring an ultimate way out to hit this pandemic but no such research made till now has been approved yet, to have the potential to bring an end to this fatal situation,” they wrote. “Although a few possible treatment choices exist at the moment yet the requirement to search for a still better therapeutic option remains persistent.”

We spoke with Arun Kumar, PhD, assistant professor, Chitkara College of Pharmacy, Punjab, India, who briefly discusses what his team reviewed, including current therapeutic approaches, the associated therapeutic efficacy, and percentage of curability. 

What existing data led you and your co-investigators to conduct this research?

As we all know, this COVID-19 pandemic poses a financial and life threatening burden to common people, as well as the heath care system. It is necessary to provide a detailed account on available therapy for COVID-19. Apart from this, our group has compiled all the related therapeutic approaches used worldwide and current clinical studies underway to tackle with this pandemic. 

What are the possible real-world applications of these findings in clinical practice?

Our studies focused on collection of data from online search engines basically on the therapeutic approaches, their therapeutic efficacy and percentage of curability.

Global laboratories are working day and night in search for an effective vaccine, many are undergoing clinical trials but their commercialization is no less than a year away. The present review highlights the current potential therapies viz., vaccines, immunotherapies, convulsant plasma therapies, corticosteroids, antithrombotic, intravenous immunoglobulins, nocturnal oxygen therapy etc. that may prove beneficial in attenuating the pandemic situation. 

Is there anything else pertaining to your research and findings that you would like to add?

Our research compiled all available therapeutic approaches for this pandemic situation. The comparison and presentation of collective data on the therapeutic advancements in mitigating the pandemic situation needs further clinical investigations in order to prove boon to mankind. 

About Dr Arun Kumar

Dr. Arun Kumar is currently working as an Assistant Professor in Chitkara College of Pharmacy, Chitkara University, Punjab, India. He obtained his PhD from the Department of Pharmacy, Jaypee University of Information Technology, Waknaghat, Solan, India (Full time Fellowship JUIT/126752) in the area of Polymeric nanocomposite hydrogel-based drug delivery system for biomedical applications.

His research and teaching carries approximately 8 years of combined experience in the area of polymeric nanocomposite drug delivery system for biomedical applications, diabetic ulcers, and various nanoformulations based drug delivery system for oral delivery of phytochemicals. As a researcher he has guided more than 10 graduate, 10 undergraduate and 1 PhD student during their research work. To date, he has approximately more than 35 international publications, 2 patents filed, 2 book chapters and my research work has been published in peer reviewed journals such as International Journal of Biological Macromolecules, Journal of Applied Polymer Science, Life Sciences, Journal of Drug Delivery Science and Technology, Current Neuropharmacology and International Journal of Molecular Sciences (MDPI) and International Immunopharmacology. 

Reference:

Kumar A, Deka Dey A, Behl T, Chadha S, Aggarwl V. Exploring the Multifocal Therapeutic Approaches in COVID-19: A Ray of Hope [published online ahead of print November 3, 2020]. doi: https://doi.org/10.1016/j.intimp.2020.107156

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