July 30, 2019
By Lisa Rapaport
(Reuters Health) - Women who experience sexual dysfunction after menopause may feel more desire and pleasure when they use testosterone treatments, a recent meta-analysis suggests.
Researchers reviewed data from 36 trials with 8,480 participants, most of whom were postmenopausal. The trials randomly assigned some women to use testosterone treatment and others to take a placebo or an alternative hormone treatment like estrogen alone or with progesterone.
Women who used testosterone experienced significantly increased sexual function and had satisfying sex more often than their counterparts who didn't get this therapy, the study found. Testosterone caused spikes in desire, arousal, orgasm, and responsiveness as well as a decrease in distress related to sexual function.
"Testosterone acts directly in the brain and influences sexual functioning at a central level (sexual desire, fantasy, thoughts, etc.) and it also increases blood flow to the genitalia so women are more likely to feel sensation of arousal and orgasm," said Susan Davis, senior author of the study and a researcher at Monash University in Australia.
Although best known as a male hormone, testosterone is important for female sexual health, contributing to libido and orgasm as well as helping to maintain normal metabolic function, muscle strength, cognitive function and mood, researchers noted July 25 online in the Lancet Diabetes & Endocrinology.
Prior research has suggested that testosterone therapy can improve sexual function in women, but the available formulations have been designed for men and evidence for their safety or for adverse side-effects in women is scant.
In the current study, side effects with creams and patches included slight weight gain, mild acne, and increased hair growth. Oral testosterone appeared to increase low-density lipoprotein (LDL) cholesterol.
The study also looked at other common reasons why women take testosterone and found no beneficial effects on cognitive measures, bone mineral density, body composition or muscle strength. No benefits were seen for depressive mood.
"This is the first study to refute the use of testosterone for anything other than low libido unless future studies show evidence of benefit," Davis said by email. "Unfortunately there are a lot of women in the USA and Australia being treated with testosterone for fatigue, depression and other invalid reasons."
There are no testosterone treatments approved specifically for use in postmenopausal women, Davis said. As a result, women use formulations made for men or use compounded, or custom-blended medicines, that may be unsafe or ineffective.
Still, results from the study should reassure women that they may benefit from using testosterone to treat sexual dysfunction after menopause, said Rossella Nappi of the University of Pavia in Italy.
"Testosterone is not an easy fix for sexual dysfunction but it should be considered ...for low sex drive, arousal, etc.," Nappi, author of an editorial accompanying the study, said by email.
Treatments with estrogen may also help women improve genital arousal and lubrication as well as vaginal dryness and pain during intercourse, Nappi said.
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Lancet Diabetes Endocrinol 2019.(c) Copyright Thomson Reuters 2019. Click For Restrictions - https://agency.reuters.com/en/copyright.html