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Psoriasis Associated With High Level of Comedication

September 17, 2020

Patients with psoriasis have a significantly higher comedication burden compared with the general population, according to a study published online in the journal Dermatology and Therapy.

“The level of comedication found in the present study reinforces the evidence of the high comorbidity load associated with psoriasis,” researchers wrote. 

The study, based in Sweden, looked at dispensed prescriptions for 4587 patients with psoriasis compared with 268,949 people without psoriasis who served as controls.  

The number of different drug dispensations was significantly higher among participants with psoriasis compared with control subjects, researchers reported. Psoriasis drugs aside, just 1.3% of patients with psoriasis did not take any other prescription drugs compared with 9.3% of the general population during the study period, which began April 9, 2008, and ended January 1, 2016. 

Oral antibiotics and painkillers were the most commonly dispensed comedications among patients with psoriasis, according to the study, which found an increased risk for opioid dispensing in the patient population. Medication dispensing related to comorbid disease was higher in the categories of anxiolytics, sedatives, chronic obstructive pulmonary disease medications, migraine medications, and erectile dysfunction medications.  

Some comedication groups showed uneven sex distribution, analysis showed. Drugs targeting obesity, osteoporosis, psychiatric disease, and antimycotics/antifungals were more frequent among women with psoriasis. Sexual dysfunction medication, meanwhile, was dispensed solely to men.

“Comorbidity highly influences the total morbidity, health care costs, and socioeconomic burden of psoriasis. It has been estimated that a third of productivity losses in psoriasis patients are attributed to psoriasis while comorbidity accounts for the rest,” researchers wrote. “We suggest that addressing comorbidities early and working with prevention are beneficial not only for patients but also a valuable investment for the society as a whole.” 

Jolynn Tumolo 


Duvetorp A, Mrowietz U, Nilsson M, Seifert O. Psoriasis is Associated with a High Comedication Burden: A Population Based Register Study [published online ahead of print, 2020 Sep 4]. Dermatol Ther (Heidelb). 2020;10.1007/s13555-020-00442-3. doi:10.1007/s13555-020-00442-3

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