How Multidrug-resistant Pathogens Make Their Way Into Hospitals

August 18, 2016

How do multidrug-resistant pathogens get into hospitals? Sometimes they come when patients are admitted.

To learn more, scientists in Germany from 6 hospitals tested 4,376 adult patients for third-generation cephalosporin-resistant Enterobacteriaceae (3GCREB) when admitted.


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We were surprised that on hospital admission almost every tenth patient is colonized with multidrug-resistant pathogens,” Dr. Axel Hamprecht of the University of Cologne said in a statement.

The researchers utilized questionnaires to better understand potential colonization factors. What did they reveal? Two factors emerged. Patients who had traveled outside of Europe, as well as those who had taken antibiotics, were more likely to test positive for the pathogens.

The research is a part of the Antibiotic Therapy Optimization Study (ATHOS). It was published in the Journal of Antimicrobial Chemotherapy.

A recent study published in the journal Infection Control & Hospital Epidemiology looked at which factors increased the risk of carbapenemase-producing carbapenem-resistant Enterobacteriaceae (CP-CRE) infection spreading in hospitals. They found that three factors contributed to transmission: mechanical ventilation; infection with another multidrug-resistant organism; and contact for more than 3 days with the infected patient.


--Stephanie Vaccaro



German Center for Infection Research. How are dreaded multidrug-resistant pathogens brought into hospitals? August 17, 2016.