Hospital-Acquired Drug-Resistant Infection Increasing

May 25, 2018

Hospital-acquired drug-resistant Acinetobacter baumannii infections in US children increased between 1999 and 2012, according to a study published online in the Journal of the Pediatric Infectious Diseases Society (doi: 10.1093/jpids/piy018).

Researchers looked at data from The Surveillance Network Database to identify trends in antibiotic resistance in infections in children caused by A. baumannii. The bacterial infection is one of the most common types of hospital-acquired infections in children in the United States.

Over the 13-year period, cephalosporin-resistant A. baumannii increased from 13.2% of infections to 23.4%, and carbapenem-resistant A. baumannii increased from 0.6% of infections to 6.1%. For both antibiotics, instances of resistance to the bacteria peaked in 2008, when the rate of cephalosporin-resistant A. baumannii was 32.5% and the rate of carbapenem-resistant A. baumannii was 12.7%.

Researchers believe antibiotic stewardship guidelines released in 2007 or infection control guidance targeting multi-drug resistant A. baumannii in health care facilities may be behind the decline that occurred after 2008.

However, between 1999 and 2012, the rate of cephalosporin-resistant bacteria among all A. baumannii grew 3% annually; carbapenem-resistant bacteria grew 8% annually.

“While we are encouraged by the slight downtrend in resistance after 2008, there is still an overall increase in these infections,” said Latania Logan, MD, chief of pediatric infectious diseases and associate professor of pediatrics at Rush University Medical Center.

“Further studies are needed to assess the most effective prevention strategies in children.”

Jolynn Tumolo

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