June 19, 2018
Treatment with methotrexate (MTX) is not associated with an increased risk of liver cirrhosis among patients with psoriasis and chronic viral hepatitis, according to the results of a recent study.
Using data from the National Health Insurance Research Database in Taiwan, the researchers identified 2417 patients with psoriasis with chronic hepatitis B and 1127 patients with psoriasis and chronic hepatitis C. Of the hepatitis B group, 370 were MTX users, and of the hepatitis C group, 174 were MTX users.
After a mean follow-up of 9 years since diagnosis of hepatitis, 125 hepatitis B patients (5%) and 120 hepatitis C patients (11%) had developed liver cirrhosis, consisting of a comparable number of MTX users and non-users (4% vs. 5% in hepatitis B patients and 11% and vs. 11% in hepatitis C patients).
“Our real-world data show that long-term MTX use may not be associated with an increased risk of liver cirrhosis among psoriatic patients with chronic viral hepatitis,” the researchers concluded.
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