American Geriatrics Society (AGS) 2012 Annual Meeting: Page 2 of 2

June 19, 2012



Oral Healthcare Lacking in Older Adults With Dementia

Older adults with dementia have poor oral healthcare, which worsens with the stage of dementia, as compared with adults without dementia, according to Thulasiram Janardhanan, MD, MPH, and colleagues from the Department of Geriatric Psychiatry, SUNY Downstate Medical Center, Brooklyn, NY. Janardhanan and colleagues reported the findings of their retrospective chart review of 136 patients examined in a university-based dementia clinic and a geropsychiatry clinic in Brooklyn, NY, from December 2009 to July 2011, during a poster session presented at the AGS annual meeting. Because there is a lack of data concerning dental care in older adults with dementia, especially among minorities, the study’s aim was to contrast various oral health measures of older adults with dementia with those of persons without dementia but who have psychiatric diagnoses.

Of the study participants, 78% were black, 13% Hispanic, and 8% white; 70% were women. The participants were divided into two groups: dementia (n=59) and nondementia (n=77). They were also placed into two cognitive categories based on their Mini-Mental State Examination (MMSE) scores: >23 (n=51) and <23 (n=73). The following oral health measures were compared between the dementia and nondementia groups: daily brushings, annual dental visits, daily flossing, problems with teeth, dental pain, denture use, and problems with dentures. Of the measures, only annual dental visits (r=.18) and flossing teeth (r=.18) reached statistical significance (P<.05). There were no significant correlations between the two MMSE groups and the dental variables.

The researchers noted that in the dementia group, having at least an annual visit to a dentist was significantly associated with the stage of dementia. Among persons with mild and moderate dementia, 71% had annual visits, whereas among persons with severe dementia, only 22% had annual visits. Because poor oral health can lead to many negative outcomes in patients, Janardhanan and colleagues concluded that the study “confirms the need for education of caregivers and increased accessibility to oral healthcare in older adults with dementia.”  —Allison Musante

The study was funded by a training grant from Health Resources and Services Administration (HRSA).


Medication Adherence in Cognitively Impaired Adults Requires Frequent Human Interventions and Further Research

There are numerous barriers to medication adherence in cognitively impaired older adults, yet studies suggest that frequent human communication interventions are more likely to improve medication adherence than non–human-reminder systems, reported Noll L. Campbell, PharmD, College of Pharmacy, Purdue University, West Lafayette, IN, and colleagues in a poster session presented at the AGS annual meeting. In a systematic evidence-based review, Campbell and colleagues conducted searches in MEDLINE/PubMed, EMBASE, PsycINFO, GoogleDocs, and CINAHL (Cumulative Index to Nursing and Allied Health Literature) for studies including community-dwelling older adults with any degree of cognitive impairment. The authors reviewed observational studies to identify barriers to adherence, and they also reviewed clinical trials targeting medication adherence to identify interventional studies. Case reports, reviews, and studies focusing on psychiatric disorders or infectious diseases were excluded from the review.

Campbell and colleagues identified three major categories of barriers: patient-reported, caregiver-reported, and those recognized by administrative databases. Patient-reported barriers included insufficient knowledge of directions and indication, difficulty understanding changes to the regimen, poor ability to remember doses, and taking more than four medications daily. Caregiver-reported barriers included difficulty scheduling medications into the care routine, difficulty keeping prescriptions filled, and cognitive impairment of the caregiver. Administrative databases also revealed common characteristics of persons less likely to adhere: female sex, age ≤75 years, minority ethnicity, and community-dwelling status.

In a summary of interventional studies, human communication systems were found to significantly improve adherence compared with non–human-based systems. Human-based systems included telephone and televideo monitoring at each dosing interval, as well as nurse-driven reminders and cueing. A study in which patients were reminded via mail to refill prescriptions, were provided with illustrated medication schedules, or both, showed no improvement in medication adherence. The authors acknowledged that their study was limited by the small sample sizes of the identified observational studies; thus, future research should include larger sample sizes. Additionally, they concluded that “moving beyond memory as the primary barrier to medication adherence should be the focus of future interventions within this population.”—Allison Musante

The study was supported by a grant from the Agency for Healthcare Research and Quality.


Herpes Zoster Vaccination Rates Vary Widely Among Older Adults

Herpes zoster (HZ), also known as shingles, is the reactivation of the latent varicella zoster virus in the sensory nerve ganglia. The most common complication of HZ is postherpetic neuralgia (PHN), which presents as severe pain that can persist for months after infection and can lead to numerous other adverse conditions. Vaccination has been shown to significantly decrease the morbidity associated with HZ and the incidence of PHN, but despite its availability, uptake is low, noted Sunil Swami, MBBS, MPH, Department of Epidemiology, College of Public Health and Health Professions, University of Florida, and colleagues in a poster session presented at the AGS annual meeting.

Swami and colleagues reported the findings of a data analysis from the 2009 Behavioral Risk Factor Surveillance System (BRFSS), which included adults aged 60 years and older in five states that used the optional shingles module (n=14,592). Differences in vaccination rates based on several demographic and health-related factors were tested using a multivariate logistic regression model. The researchers discovered trends in those persons most likely to receive the HZ vaccine.

Overall, the researchers found vaccination uptake was 11.4% among the respondents; however, once respondents with missing values for key variables were excluded, the overall vaccination uptake was 13.1%. The model showed that compared with respondents who had a check-up within 1 year, those with a check-up within 1 to 2 years and those with a check-up more than 2 years before had reduced odds of receiving the vaccine (odds ratio=0.84 and 0.37, respectively). After adjusting for confounding factors, there was no association between having health coverage or reporting an inability to see the physician due to the cost of the HZ vaccine.

The authors also determined from the study that those more likely to receive HZ vaccination were older adults receiving a flu shot, adults older than 65 years, women, married persons, adults generally in good health, older adults with an annual income of more than $50,000, and adults with a college or technical education. Current and former smokers were less likely to receive the HZ vaccine.—Allison Musante


Unsteadiness Common in Older Adults Receiving Post-Acute Care in Skilled Nursing Facilities

Unsteadiness, defined as a subjective sense of loss of equilibrium or balance with regard to the environment, is known to be common among institutionalized older adults, but little research has been conducted on this phenomenon in this population. In a poster presented at the AGS annual meeting, Srihari Bangalore, MD, and Susan E. Hardy, MD, University of Pittsburgh School of Medicine, Division of Geriatrics, Pittsburgh, PA, outlined the prevalence of unsteadiness and the characteristics associated with it among community-dwelling adults newly admitted to skilled nursing facilities for post-acute care. Bangalore and Hardy found that while other general symptoms are associated with unsteadiness, hospital diagnoses were not.

Bangalore and Hardy’s poster included information on the first 125 participants enrolled in their study. These patients were individuals aged 65 years and older who were admitted to a skilled nursing facility for rehabilitative post-acute care following a hospital admission for an acute condition. Patients were excluded from the study if they were a resident in a skilled nursing facility before their hospital admission, had significant cognitive impairment and no proxy, did not speak English, or had very limited functional status prior to hospitalization. All patients were enrolled within the first 72 hours of admission and were followed until discharge. To measure unsteadiness, patients were asked if they had experienced unsteadiness in the past 2 days. If they responded in the affirmative, the modified Edmonton Symptom Assessment System was used to determine if it was mild, moderate, or severe. Other assessment measures included the PHQ-9 (Patient Health Questionnaire-9) to ascertain depressive symptoms; CIRS (Cumulative Illness Rating Scale) to measure multimorbidity; performance of seven activities of daily living (bathing, dressing, transferring, walking, eating, grooming, and toileting) to determine functional status; CAM (Confusion Assessment Method) to assess for delirium; and MoCA (Montreal Cognitive Assessment) to determine cognition.

Of the 125 patients, 90 reported unsteadiness. In those with unsteadiness, 40% noted it to be moderate, 18% to be severe, and 14% to be mild. When examining the characteristics of patients reporting unsteadiness versus those who reported no unsteadiness (n=35), the investigators found that patients were more likely to experience unsteadiness if they were fatigued (P<.001), dizzy (P=.04), had difficulty thinking (P=.01), or had nausea (P=.03). Patients were also more likely to report unsteadiness if they underwent any surgery while in the hospital (P=.01), had depressive symptoms on the PHQ-9 (P=.01), or had delirium (P=.03).

Based on their findings, Bangalore and Hardy note that “Unsteadiness is more prevalent than dizziness and the two symptoms are only modestly associated, suggesting that patients do not perceive them to be the same.” They concluded that “Further research on medications may shed light on other possible causes of unsteadiness in this population.”—Christina T. Loguidice

This research was supported by the National Institute on Aging (R03AG032291); Beeson Career Development Award (K23AG0309770, with support from the Hartford and Starr foundations and Atlantic Philanthropies); and the Pittsburgh Claude D. Pepper Older Americans Independence Center (NIA P30 AG-024827).